That is complex.Autism is a neurological abnormality in which the production of long dendrites is hindered by the ingested space of short dendrites. In fact, what goes wrong with this abnormality is the ‘ pruning ‘ (the opposite of Synapse Genesis) of the short dendrites. The cause of the disruption of that process can be many.
The following list might give insight on how complex it intertwines.It is an incomplete list. A high statistical correlation has been found in the list of the following genes and gene variants:
CDH8, CDH9, CDH10: These genes play a role in neuron cell adhesion of molekulen.
MAPK3: This gene plays a role among other things IN the MAP Kinase process in the body (see TAOK2).
SLC6A4: Mutations on this gene cause a condition called hyperserotony.Serotonin is a hormone that, among other things, plays a role in stress regulation.
CACNA1G: This gene plays a role in voltage deactivation and conduction of cells.Rapid communication of nerve cells goes through the flow of a signal. Nerve cells look very much like brain cells.
GABRB3, GABRA4: These genes play a role in the development of brain parts such as the cerebellum, hippocampus, thalamus and medulla oblongata.
EN2: This gene plays a role in the development of pattern formation in the development of the central nervous system.The gene is also widely used in the diagnosis of prostate cancer in men. It is suspected that it also plays a role in hormonal matters.
D3S3715, D3S3715: Of these genes it is suspected that it also plays a role in the disease leukenalopathy.Some forms of this disease are a demyelinizing disorder to the central nervous system. Some of its forms can be activated by polyomaviruses, these viruses are also found in birds. Their close relatives are Onco viruses (cancer-causing viruses, for example the notorious HPV, cervical cancer). It is a controversial idea and proof of that is lacking.
Reln: This gene plays a role in synaptic plasticity and the development of the central nervous system.It exhibits not only a high correlation with autism, but also with bipolar disorder, schizophrenia, epilepsy and Alzheimer’s.
SLC25A12: The gene plays a role among other things in myelinisation of nerve cells.Myelinisation is often also a problem in the development of the disease Multiple sclerosis. It probably also plays a role in the development of white mass in the brain. Women are known to have more white mass than men and also have more long interconnections.
HOXA1, HOXB1: These play a role in cell differentiation and the development of the brainstem in the embryo.The brainstem plays an important role in heart rate, breathing, eating, sleep-wake rhythm and consciousness.
PRKCB1: The gene plays a role in the production of enzymes for the absorption of sugar, but also in receptors that play a role in anxiety regulation.It also plays a role in cell death and clearance of tumors in the body.
TAOK2: Other research has shown that this gene is interacting with other genes that play a ROLE in MAP Kinase.This process plays a role in cell division, cell death and the immune system. That could indicate that an autism spectrum disorder may also be the cause of an auto-inmuundisease. This too is a controversial idea and proof of that is lacking.
MECP2: abnormalities/Mutations on this gene can cause the impairment of Rett (Rett is often classified within the autistic spectrum).
UB3A: plays a role in genetic imprinting.
SHANK3: plays a role in regulating neurotransmitters.
NLGN3: plays a role in the synaptic membrane.
With: plays a role in the gastrointestinal tract (many people in the spectrum often also have stomach and intestinal complaints) and a role in the development of the cerebellum and neuron receptors.The cerebellum in the brain plays a role in attention, language, anxiety regulation and fine motor skills.
NRXN1: plays a role in communication between neurons.
CNTNA2: plays a role in potassium intake.Potassium is widely used in nerve cells.
FOXP2: plays a role in speech and language.
GSTP1: This gene plays a role in maternal metabolism during pregnancy, so it may be in some cases that autism does not inherit so much, but may be a congenital abnormality.For example, there are also statistical links between Meconium in the amniotic fluid in pregnancy and autism in the child, but the causal relationship has not yet been found. So it seems that autism is not simply a matter of inheritance, but, for example, may be a similar consequence if you see, for example, Resus antagonism but do understand the child survives but so does autism. This too is a controversial idea and proof of that is lacking.
Prl, PRLR, OXTR: These play a role in the production of the prolactin hormone.That hormone has multiple roles in the body, but also plays a role in inhibition, which may indicate that it may play a role in the development of ADHD and ADD. It is estimated that a quarter of people in the autistic spectrum also have ADHD or ADD. That already indicates how difficult it is to investigate which genes actually play a cause in autism and what may be another neurological abnormality that exhibits comorbidity with autism.
Asked a geneticist last year.
If I was remember correctly there were about 20,000 genetic markers that may have more or less to do with ASD.
It is therefore very difficult to establish through genetic material or someone has ASD.
At the same time, there are examples where genetic causes have been found for ASD.